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However, since iron is a cellular transition element and its ionic forms participate in electron transfer reactions, it can also produce free radicals

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332,333,334 Specifically, IR leads to compensatory hyperinsulinemia, which stimulates GnRH gene transcription through MAPK pathway in PCOS and increases LH pulse secretion, thereby significantly increasing ovarian androgen synthesis

This modification can affect the structure and thus the function of the affected histone proteins

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