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The damage occurred before reconstitution

[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Galeeva J.S., Fedorov D.E., Starikova E.V., Manolov A.I., Pavlenko A.V., Selezneva O.V., Klimina K.M., Veselovsky V.A., Morozov M.D., Yanushevich O.O., et al

They can arise anywhere in the body, including the upper extremity, but are uncommon in the hand

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(2016) reported that the absence of BMAL1 in mice not only disrupts circadian rhythms but also increases oxidative stress, impairs mitochondrial function, and perturbs metabolic pathways, pointing to a clock-independent role for BMAL1 in maintaining redox balance, proteostasis, and tissue integrity