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Treatment with GGC (200 M) provided significant protection from exposure to oligomeric A 40

For instance, the dysregulation of Cu transport ATPase A (ATP7A), ceruloplasmin (CP), superoxide dismutase 3 (SOD3), and other Cu proteins in pancreatic -cells may lead to intracellular Cu accumulation, triggering increased ROS generation and causing pancreatic islet damage, ultimately resulting in DM (59)

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Similarly, deletion of the Ca 2+ sensor STIM1 leads to spontaneous activation of the STING-TBK1-IRF3 pathway, which results in type I IFN-mediated ER stress (130)

Selecting female mice in estrus and checking plugs