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As for the role that caffeine has in the purported benefits of the coffee enema, drinking coffee is a far more effective method for increasing the amount of caffeine in your blood (and hence causing vasodilation to potentially send toxins from the blood into the colon, or causing increased bile acid secretion to potentially facilitate liver detoxification) compared to administering it at the other end

10.1074/jbc.ra118.003129 213 ZhaoY.HuQ.ChengF.SuN.WangA.ZouY.et al (2015)

CHROMIXS: automatic and interactive analysis of chromatography-coupled small-angle X-ray scattering data

doi: 10.1038/s41575-019-0173-3 58 MuYMaimaitiyimingRHongJWangYZhaoYLiuRet al

10.3791/51439 J

Cells were treated with BSO or DEM