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A general limitation of this review should be highlighted: while the cited studies originate from all continents, to the best of our knowledge, no comparisons have been conducted across different ethnic groups

Plates were read at 450 nm immediately after adding stop solution (3 M H 2 SO 4 )

It is important to note that metformin can significantly affect the levels of various metabolites, including those involved in the glucose metabolism, lipid metabolism, tricarboxylic acid cycle (TCA), and urea cycle (t Hart et al., 2018a)