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European Journal of Clinical Pharmacology

The protective impact of berberine against doxorubicin-induced nephrotoxicity in rats

The UTRs are indicated by the thin black line

The study found that the iron concentration in the vitreous of human OT patients decreased significantly, suggesting that ferroptosis is involved in the pathogenesis of OT (Yamada et al., 2023)

In the phase I dose-escalation portion, subjects were directed to consume 4-oz of grape juice or placebo daily for 2 weeks (weeks 02), 8-oz for 2 weeks (weeks 34), and finally 16-oz daily dose of either treatment (weeks 56)