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Functional enrichment analyses (GO/KEGG) identified ketone body biosynthesis as the most upregulated pathway in IPA-treated goblet cells, Paneth cells, and enterocytes, constituting core modules of butanoate metabolism (Fig

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While this is beneficial under normal circumstances, it may inadvertently support tumor growth and resistance to therapy by promoting cellular survival pathways

4-HNE reacts mainly with sulfhydryl groups of thiols in proteins to form Michael adducts and these adducts subsequently undergo secondary reaction to form cyclic hemiacetals (119, 135)

-1 antitrypsin promotes semimature, IL-10-producing and readily migrating tolerogenic dendritic cells

Stress-induced immune dysfunction: implications for health