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Combining the different arms of gut microecology, iron metabolism, cell death in this hypothesis, it offers a new explanatory model for investigating gut-joint axis in OA and proposes possible targets for OA intervention strategies including changes of gut microbiota or ferroptosis

10.1021/ar400250z 31 LinY.ZhaoA.TaoY.RenJ.QuX

V5-tagged nanobody was developed to detect intra-cellular binding proteins [120]

The complex structures show that the aldehyde groups covalently bind to C145 of the catalytic dyad to inhibit M pro activity

Review and editing: R.S., B.A.L

A sybody against the maltose-binding protein 59 was used as a negative control