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Hosie MJ, Addie D, Belk S, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hartmann K, Lloret A, Lutz H, et al

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Gonzlez-Guerra JL, Castilla-Cortazar I, Aguirre GA, Muoz U, Martn-Estal I, vila-Gallego E, Granado M, Puche JE, Garca-Villaln A (2017a) The sole partial insulin-like growth factor (IGF-1) deficiency reduces heart contractibility, angiotensin II sensibility, and alters gene expression of structural and functional cardiac proteins Gonzlez-Guerra JL, Castilla-Cortazar I, Aguirre GA et al (2017b) Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins

This interaction facilitates the ubiquitination and subsequent proteasomal degradation of Nrf2, keeping its levels low

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