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It was tolerated quite well. Frias said the tolerability may have been due to the dose escalation protocol

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The absence of repression of the oligopeptide systems in CDMg, which contains the 20 amino acids, compared to CDMg, YE might be due to the low efficiency of amino acid uptake, limiting the availability of branched-chain amino acids inside the cell (Guedon et al., 2001a,b)

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