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These findings underscore the importance of exploring and optimising treatment scheduling to maximise their efficacy, particularly for future platinum drug combinations

Increasing amounts of NADPH (1250 M) were subsequently added to the wells and the solutions were imaged on an LSM880 confocal laser scanning microscope (Carl Zeiss AG, Oberkochen, Germany) with a 63x immersion objective (LD LCI Plan-Apochromat 63x/1.2 Imm Corr DIC M27) using a 440 nm pulsed excitation laser (LDH-D-C-440, 40 MHz repetition rate) managed by a PicoQuant FLIM module (Sepia PDL828-S, PMA Hybrid 40, MultiHarp 150 4N, Time Harp 260 PICO Dual) (PicoQuant, Berlin, Germany)

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Paraquat-treated mice group has higher ROS generation as compared to the control group which can be seen via Dichlorofluorescein (DCF) fluorescence intensity

Schabbauer, More than just protein building blocks: How amino acids and related metabolic pathways fuel macrophage polarization