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Cleve Clin J Med 83(6):463471 Coe FL, Evan A, Worcester E (2011) Pathophysiology-based treatment of idiopathic calcium kidney stones

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Investigated various glutathione derivatives in vitro and found that certain forms (e.g., GSHMEE) effectively reduce melanin and tyrosinase activity, increasing the pheomelanin/eumelanin ratio

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Thus, by using the electrochemical gradient of these ions across the plasma membrane as an energy source, the transporters are capable of effectively accumulating L-glu and L-asp in cells against their steep intra- to extracellular concentration gradients