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144 Morevoer, Zhao et al

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Depletion of GSH is observed in patients with hepatitis virus, HIV, HSV-1, etc

Metabolic analysis revealed significant increases in the concentration of several metabolites known to be beneficial in the treatment of autoimmune diseases, including acetyl-CoA, ascorbic acid, citrate, butyryl-CoA, glutathione, glycoursodeoxycholic acid (GUDCA), and acetic acid, while significant decreases were observed in isoleucine and urea, among others (Supplementary Table 2)

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Importantly, within 1 hour from dTAG V -1 administration, most of METTL9-FKBP-FLAG was degraded in mESCs, as shown by WB (Fig