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However, long-term excessive intake (usually referring to more than 1015 g per day) may cause gastrointestinal disturbances, manifested as abdominal pain, diarrhea, or nausea

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Mathieu C, Van Etten E, Gysemans C, Decallonne B, Kato S, Laureys J, et al

For optimum catalytic activity, these enzymes also require co-factors such as selenium, iron, copper, zinc, and manganese