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3.2 Obesity and adipose inflammation In addition to the systemic effects of dyslipidemia and excess lipid burden on metabolism, circulation, and organ function, the accumulation of bioactive lipid species within macrophages promotes pro-inflammatory activation, sustaining chronic low-grade inflammation and contributing to cardiometabolic disease ( Figure 3 )

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Quercetin, fisetin, piperlongumine (PL), and natural phytochemicals present senolytic potentials in in vitro studies

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