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Burns 29 (8), 769777

The new Wegovy pill, meanwhile, is approved for 25 mg daily

doi: 10.1177/02611929221118001 315

TS inhibition by 5FU regulates mitochondrial biogenesis through mTORPGC1 signalling 5FU has a multimodal mechanism of action: promoting DNA damage directly via its metabolite FdUTP or by inhibition of TS via FdUMP, depleting the pool of thymidine available for DNA synthesis, and causing RNA damage via FUTP (Fig

Food as medicine

It is tempting to speculate that the interaction between GABAergic and glutamatergic synapses could involve a bidirectional crosstalk that include signals from the excitatory synapse that regulate GABAergic synapse strength and persistence (Marsden et al., 2010)