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Conversely, genes associated with inflammation and immunityrelated pathways (cytokine receptor interactions, the chemokine signaling pathway, and the IL17 signaling pathway), cellcell interactions, cell structurerelated pathways (cell adhesion molecules, focal adhesion, and the ECMreceptor interaction), and signal transduction pathways (the Hippo signaling pathway and the PI3Akt signaling pathway) were downregulated (Figure 5G), indicating that NMN treatment can alleviate inflammatory responses in the ovarian tissues of aged mice and that it can regulate processes such as cell adhesion, migration, and extracellular matrix remodeling, thus affecting physiological processes such as cell growth and proliferation

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