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This approach has been designed to determine the maximum suggested starting dose, even though lower starting doses may also be suitable in some first-in-human clinical trials

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[DOI] [PubMed] [Google Scholar] 144.McNeil J.J., Robman L., Tikellis G., Sinclair M.I., McCarty C.A., Taylor H.R

Metaplasticity: tuning synapses and networks for plasticity