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Investigators have assessed multiple administration routes, including subcutaneous, intramuscular, intravenous, oral, and topical delivery in experimental models

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Subsequently, reduced iron Fe 2+ enters enterocytes through divalent metal transporter-1 (DMT1) in the apical membrane (51), is transported into the blood circulation through Ferroportin1 (FPN1) on the intestinal epithelial cell membrane, and is then converted to Fe 3+ by heparin (Hp) or ceruloplasmin (52)

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Promotes the release of stored toxins

Kumai T, Matsuda Y, Ohkuri T, Oikawa K, Ishibashi K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H