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Cagrilintide is engineered to provide prolonged receptor activation compared to native amylin

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A reduction of the N-terminal peptide bond of 25 , with the ambition to achieve a compound even more resistant to proteolytic cleavage, provided 26 (Barlow et al., 2020)

FIGURE 3 In summary, these experimental results collectively confirmed the damage and aging characteristics of endothelial cells caused by OGD treatment