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The application is made with the help of very fine-tipped needles

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Furthermore, most studies prioritize symptom improvement (e.g., pain reduction) as endpoints, with a pronounced lack of robust evidence demonstrating structural modification (e.g., cartilage preservation via quantitative MRI)

USA 105 , 61856190 (2008)

Indeed, accumulating evidence based on preclinical studies has identified ERK5 activation as a mediator of resistance to vemurafenib (BRAFi) and trametinib (MEKi) [54], and therefore, the combined targeting of ERK5 and ERK1/2 pathways results in better outcomes [55]