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Pathophysiology of MSL Hypothesis 1: Brown Adipose Tissue The dorsocervical fat pad (buffalo hump) is thought to be a location of brown adipose tissue found both in MSL (264,269,270) and HIV-associated lipodystrophy (271-274) suggesting that the abnormal fat tissue in both of these conditions arises from brown adipocytes (275)

Nature 425 , 191196 (2003)

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