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The patients using a topically applied flavonoid intervention with EGCG in the trial of Zhao et al

Soares et al

Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways

239 The body increases thermogenesis, primarily through non-shivering thermogenesis in brown adipose tissue, which involves increased FAO and uncoupling of OXPHOS to generate heat rather than ATP