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Description

Addition of 5 g/mL BPC-157 stimulated a morphological change in HUVECs without significantly increasing the tube network formation, whereby increasing the dose to 10 g/mL caused greater tube formation compared to control

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Early studies in cats using various administration routes (IV, intra-arterial, intrarenal) and dosages have raised minimal safety concerns, however efficacy results were mixed and follow-up durations were short (23 months)

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Conversion of proIGF-1 to mature peptide requires the endoproteolytic cleavage of the E-domain by proprotein convertases, such as furin, which processes proproteins at highly conserved, unique pentabasic motif 3,4

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