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BPC157 has demonstrated an exceptional safety profile across multiple studies with no evidence of organ toxicity, mutagenicity, or carcinogenicity. Sikiric et al., Journal of Physiology and Pharmacology Long-Term Safety and Human Use Although human clinical trials are limited, the peptide has been used extensively in animal models and self-experimentation circles with no long-term complications reported

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Neurochem.Shortened spadin analog PE-22-28: fast antidepressant action, increased hippocampal neurogenesis and synaptogenesis in rodent models

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2 Materials and Methods 2.1 Subject Recruitment In total, 22 Chinese patients with MS, including 20 RRMS and two PPMS cases, who were diagnosed based on the revised version of the 2005 McDonald criteria (94), were recruited from eastern China from December 2018 to January 2020