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Similar content being viewed by others Main Over the course of millennia, cells have evolved sophisticated defense pathways to maintain their homeostasis against external perturbations 1 , which typically involve sequestering 2 , degradation 3 and clearance of the toxins 4

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Oxidative damage has been linked to high levels of eryptosis through an increase in the intracellular free Ca 2+ concentration, as evidenced by in vitro studies [24, 134, 300, 301] in patients intoxicated with lead [302], and in diabetic patients with chronic renal damage [303]