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Submucosal UFs generally bulge into the uterine cavity and are more likely to affect fertility due to their proximity to the endometrium, distortion of the endometrial cavity, and interference with embryo implantation and placentation (Figure 4)

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Moreover, TMZ-mediated O6-methyl (O 6 -Me) guanine damage was shown to trigger an elevation in MMR, mediated by MLH1 and DNA MMR protein MSH2 (MSH2)

Some fiber, called soluble fiber, dissolves easily in water

Various potential therapeutic targets have been identified for enhancing efferocytosis, including OPN, CysLT2R, opioid receptor antagonist -funaltrexamine, and mitochondria-targeted drugs (Table 1, Fig

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