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The practical minimum appears to be every 48-72 hours for research protocols targeting sustained neuroplasticity

26 For most of these nanotechnologies, there is little evidence of scale-up and manufacturing potential, while evidence of efficacy in large animal models is scant

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The authors have demonstrated that LS-associated mutations disrupt the mitochondrial network in cerebral organoids, and they suggest that the mitochondrial network in LS lines are more fragmented than in the control, which could be associated with defects in respiratory capacity and developmental disorders