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These studies have typically focused on the use of neuron-like cell lines or neurons that are not normally affected by the specific aggregated protein being studied

390,391 This has led to its application in monotherapy and in combination with chemotherapeutic drugs in phase I and II clinical trials (NCT04068597, NCT03568656), with the potential to improve therapeutic strategies for both advanced solid tumors and hematological malignancies

10.1248/bpb.33.844 [DOI] [PubMed] [Google Scholar] Maurer K., Ihl R., Dierks T., Frlich L

10.1016/j.tcb.2014.04.002 89 InoueN.MatsudaF.GotoY.ManabeN

TRP channels are polymodal ion channels that have the role of integrating and transmitting a variety of environmental stimuli, including physical stimuli such as mechanical and thermal, and/or chemical stimuli such as pH and plant-derived compounds