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2.1.1.1 All- trans retinoic acid (ATRA) CD38 expression can be modulated both in vitro and in vivo through the nuclear retinoic acid receptor ( in vivo use, has proven effective in enhancing CD38 levels in several ex vivo myeloma cell preparations, leading to improved efficacy of therapeutic antibodies ( in vivo efficacy in combination with Daratumumab was called into question in a clinical trial involving relapsed/refractory (RR) MM patients

doi: 10.1007/s12035-016-0170-2 430 De BellisABellastellaGPerniceVCirilloPLongoMMaioAet al

Science 316: 10391043 [DOI] [PubMed] [Google Scholar] Epstein J.A., Shapiro D.N., Cheng J., Lam P.Y., Maas R.L

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Statistical Analysis Univariate analyses were performed to compare fold changes, calculate the areas under the curve (AUC) and determine statistical significance

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