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Nutrients 8 (11), 690 (2016)

At the structural level, tight junctions between epithelial cells loosen under stressgluten exposure in celiac disease, NSAIDs, alcohol, infections, or chronic inflammation

By isolating the trans-isomer, pharmaceutical developers produced a compound with a cleaner pharmacokinetic profile: enclomiphene is absorbed quickly, reaches peak plasma concentrations within two hours, and is cleared within about 24 hours, allowing for predictable daily dosing [1]