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Lysosomal inhibition appears to be a promising therapeutic approach in preclinical studies, and HCQ clinical trials have produced encouraging but mixed results (1, 32)

10.1046/j.1471-4159.2003.01854.x 261

Central and peripheral mechanism of MOTS-c attenuates pain hypersensitivity in a mice model of inflammatory pain

Lin K, Chowdhury S, Zeineddine MA, Zeineddine FA, Hornstein NJ, Villarreal OE, Maru DM, Haymaker CL, Vauthey JN, Chang GJ, Bogatenkova E, Menter D, Kopetz S , Shen JP

The second class of inducers can directly inhibit GPX4 and cause ferroptosis

The present study investigated effects of NiO-NP on the crucial stress alleviation mechanism Ascorbate-Glutathione Cycle (Asa-GSH cycle) in the model plant Allium cepa