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Further investigation is necessary to enhance our understanding of the role of autophagy in the progression of iron overload-related damage and to develop innovative therapeutic strategies that target autophagic pathways

The "evidence base" column is a deliberate honesty check: it flags how much of each estimate rests on preclinical work versus human observation

First discovered in 1969 by McCord and Fridovich, SOD has since been recognized as an essential component of cellular antioxidant systems

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Cluster 2: Antioxidant Defense Oxidative stress the accumulation of reactive oxygen species that damage cells, proteins, and DNA is a central mechanism of biological aging