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doi: 10.1073/pnas.1517124112 164 AhlersLRHTrammellCECarrellGFMackinnonSTorrevillasBKChowCYet al

C4a also induces the generation of reactive oxygen species (ROS) via NADPH oxidase, contributing to oxidative stress, mitochondrial dysfunction, and downstream redox-sensitive signaling cascades such as NF-B and AP-1

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