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Nat Immunol 9(8):866872 Meister A, Anderson ME (1983) Glutathione

doi: 10.1016/j.cell.2022.06.003 162 BeharierOTyurinVAGoffJPGuerrero-SantoroJKajiwaraKChuTet al

These oxidative injuries have a direct effect in the mitochondrial electron transfer, resulting in an enhanced electron leak and ROS generation that lead to a vicious circle of mitochondrial dysfunction and oxidative stress

and 100 M GSH ethyl ester for 10 min

Lyophilised GHK-Cu powder (unreconstituted) is stable at 20C (standard freezer temperature) for 1224 months without refrigerationthough "freezer storage" is technically refrigeration at sub-zero temperatures

Funding This work was supported by Shenzhen Basic Research Project (Xiongjuan Li, JCYJ20230807115301004), National Natural Science Foundation of China (Xiongjuan Li, 82501526), Sanming Project of Medicine in Shenzhen (Zhiheng liu, SZSM202211007), Shenzhen Medical Research Fund (Zhiheng liu, C2401016)