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The authors further demonstrated the role of TLR-4 in mediating brain injury by generating mice lacking TLR-4 in microglia

The exposure to LPS was associated with increased number of total cells (1.9x10 5 cells, 95% CI: 0.9x10 5 to 3.0x10 5 cells), whereas there were slightly lower numbers of total cells in the LPS-exposed mice that also received high-dose CB (-0.5x10 5 cells, 95% CI: -1.5x10 5 to 0.6x10 5 cells) relative to the LPS-exposed mice (Table 1)

National Kidney Foundation

The ratio of GSH to GSSG serves as an indicator of cellular health and oxidative stress levels

In other cell types, arginine synthesis by citrulline is very low but dramatically increases when inducible nitric oxide synthase (NOS) increases (Fig