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M6A modifications are reversible and have been shown to control splicing, stability, and translation of the transcriptome (94, 95)

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Then, we extracted corresponding isotopologues for individual metabolites and characterized the isotopologue pattern similarity for the reaction-paired metabolites (Fig

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First, to create a basis for our research, we generated isogenic induced pluripotent stem cell (iPSC) lines with mutations affecting different parts of the ALS-associated SOD1 gene