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Furthermore, heavy drinkers exhibit elevated levels of peripheral inflammatory markers such as interleukin-6 (IL-6) and C-reactive protein (CRP), which cross the bloodbrain barrier to promote neuroinflammationa shared pathway in both ethanol-induced neurotoxicity and depression (Adams et al

The antioxidant system is important in the re-establishment of oxidative homeostasis, on the contrary, may increase oxidative stress conditions and lead to cell death, senile aging, and disease decompensation

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This lactate is then exported by MCT1 and MCT4 transporters and imported into neurons via MCT2, where it fuels neuronal ATP production [295, 296]

Comparative behavioral, biochemical and pigmentary effects of MPTP, MPP+ and paraquat in rana pipiens

1c), as excessive membrane affinity hinders efficient transmembrane passage to reach intracellular targets, directly impairing degradation activity even when the warhead is optimized