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Goren M

Sirtuins are a class of NAD+-dependent enzymes that are vital for maintaining intracellular homeostasis [86]

Approaches such as intrathecal, intracerebroventricular, and intraparenchymal injections, as well as transient BBB disruption, have been employed to deliver drugs with limited CNS bioavailability (Ganger and Schindowski, 2018

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However, our mechanistic understanding of how ABHD11 functions as a nonprotein deglutarylase provides the necessary foundation for exploring the potential utility of targeting ABHD11 in different immune cell populations