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However, prolonged or high-dose ketamine exposure induces a compensatory upregulation of NMDARs, increasing intracellular calcium ion influx and ROS production, ultimately leading to neuronal apoptosis ( In animal studies, antagonism of NMDA receptors in intermediate neurons of the forebrain and thalamus reduces GABAergic function

Accordingly, we observed that lactational body weight loss was significantly exacerbated by increased energy or AA intake during gestation, with the HE-HAA group exhibiting the most pronounced weight loss due to the cumulative effects of elevated energy and AA intake

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