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Eur J Pharmacol 2010, 638 (13) : 12833

Both NOX and inducible nitric oxide synthase (iNOS) are vital in generating enhanced ROS levels within phagocytes via oxidative burst to kill invading pathogens ( 2 - produced by NOX is dismutated into H 2 O 2 by superoxide dismutase1 (SOD1), whereas nitric oxide produced by inducible nitric oxide synthase (iNOS) reacts with O 2 - resulting in peroxynitrite production ( Mitochondria are considered as the redox-active compartment within the cell, accounting for nearly 90% of oxygen utilization ( 2 -

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[DOI] [PubMed] [Google Scholar] 115.Tavafoghi M., Cerruti M

Indeed, aging muscles produce excess TGF- which induces high levels of pSmad3 in satellite cells [22], thus antagonizing Notch and satellite-cell proliferation

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