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Caution is recommended in patients with a history of gastrointestinal disease, asthma, hypertension, heart disease, or kidney disease

Thus, for example, both gene transcription (Dattani and Barahona, 2017) and translation (Dastidar and Nair, 2022) will show stochastic elements, resulting in spontaneous changes in protein synthesis that vary from time to time during development in an individual, and between individuals

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In several reported pediatric cases, ingestion of large amounts of alpha-lipoic acid (for example, 2400 mg in a toddler) led to serious reactions such as seizures, loss of consciousness, or metabolic acidosis

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