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Mice lacking Mfn 1 and 2 in the skeletal muscle have been shown to have a dramatic reduction in mitochondria content and reduced oxygen consumption

Congenital heart defects are the most common birth defects in humans, and folate plays a critical role in heart development. Research shows impaired folate transport causes cell death concentrated in the exact regions where most congenital heart defects originate [21]

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However, in the present study, we repeatedly demonstrated that curcumin increased intracellular ROS levels in order to inhibit tumor cell growth