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Dietary considerations aim to ensure they receive sufficient nutrients critical for their growth, brain development, and behavioral health

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However, the proteins identified as differentially expressed between non-splenectomized -thalassemia/HbE patients and healthy volunteers included a number of cytoskeletal proteins (F-actin -capping protein subunit beta, myosin light polypeptide 6, myosin regulatory light chain 12A, myosin-9, Rho GDP-dissociation inhibitor 2, transgelin-2, PDZ and LIM domain protein 1, and tropomyosin alpha-4 chain) as well as heat shock protein 70 kDa protein, integrin alpha IIb, beta-2-microglobulin, hemoglobin subunit beta, platelet factor 4 (or chemokine (C-X-C motif) and leukocyte elastase inhibitor

It has been shown to induce apoptosis by activating pro-apoptotic proteins (e.g., Bax, p53) and inhibiting antiapoptotic factors (e.g., Bcl-2) (38)

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Upon selenium supplementation, there is a preferential accumulation of selenium in the thyroid [137]