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Mutations in the relevant sites of MTHFR gene can result in a decrease in the enzyme activity of the MTHFR protein, leading to a deficiency of methylenetetrahydrofolate, which can eventually lead to a decrease in the degree of DNA methylation and microsatellite instability, and ultimately can induce colorectal neoplasm [2, 3, 17]

Chen YS, Guo Q, Guo LJ, Liu T, Wu XP, Lin ZY, et al

Cancers 8 (7), 63

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In more serious situations, a temporary or permanent move may be the only option to ensure a healthy recovery