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Always start with the lower dose and increase only after assessing tolerance

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The anti-ferroptotic potential of other synthetic phenolic compounds, such as 1,8-tetrahydronaphthyridinols has been demonstrated, where the inherent radical-trapping antioxidant reactivity of 1,8-tetrahydronaphthyridinols was similarly effective as ferrostatin-1 and liproxstatin-1 at subverting ferroptosis triggered by either genetic or pharmacological inhibition of the hydroperoxide-detoxifying enzyme GPX4 in mouse fibroblasts and hippocampal cells (81)

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Wijesekera LC, Nigel Leigh P (2009) Amyotrophic lateral sclerosis