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This paper shows that low-threshold spiking interneurons undergo a hyperpolarization mediated by GIRK channels that surprisingly occurs cell-autonomously through endocannabinoids, providing an example of autaptic transmission involving GIRKs

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That does not automatically mean better results

2011 Sep;12(8):453-62

Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death

HUBERMAN: But in addition to that, that you really think about using the minimal effective dose and that you use perhaps even the mildest of these different compounds in order to make sure that you don't desensitize any of the receptor pathways