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Neuroscience, 137 (2), 393399

However, the optimal dosage, administration route and long-term safety of NADPH precursors remain unvalidated in large animal models, and the crosstalk of NADPH metabolism, iron homeostasis and retinal inflammation is poorly understood, limiting clinical translation of NADPH-targeted therapies and requiring further investigation

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Identifying these triggers is part of the "Live with Intention" approach, as it allows us to address the root causes of depletion before reaching for a bottle