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J.BarbasC.DaiberA.et al

Among these, endothelial dysfunction and vascular remodeling are central to both disease initiation and progression

But I do think going to somebody who has an outside perspective, it doesn't necessarily have to be a therapist

Succinate affects the stability of HIF-1 by inhibiting prolyl hydroxylase domain enzymes (PHDs), which are a class of KG-dependent dioxygenases that can regulate HIF-1 stability in an oxygen-dependent manner, preventing its degradation (117, 118)