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Conversely, copper chelation reduces PD-L1 levels by promoting its ubiquitination and degradation, thereby enhancing T cell infiltration [232]

The initiation of ferroptosis is deeply integrated with amino acid metabolism (glutamate/cystine balance), lipid metabolism (PUFA availability) and metal homeostasis (iron regulation)

The core part of this work has now been published in the

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Cannabinoids and myocardial ischemia: novel insights, updated mechanisms, and implications for myocardial infarction